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# CITATION.cff file created with {cffr} R package
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cff-version: 1.2.0
message: 'To cite package "tsahr" in publications use:'
type: software
license: GPL-2.0-or-later
title: 'tsahr: Trial Sequential Analysis for Meta-Analyses of Hazard Ratios'
version: 0.2.8.18
abstract: Performs Trial Sequential Analysis (TSA) for meta-analyses of time-to-event
  outcomes reported as hazard ratios. Implements the Schoenfeld required-events sample-size
  formula generalised for unequal allocation, the Diversity (D-squared) heterogeneity
  adjustment of Wetterslev et al. (2009), and O'Brien-Fleming-type alpha- and beta-spending
  trial sequential monitoring boundaries computed at the inverse-variance information
  based on observed study-level log-HR standard errors (not merely event counts),
  via a compiled (C++) recursive numerical integration engine ported from the R package
  'RTSA' (Soerensen, Olsen, Lange and Gluud; an R implementation of the Trial Sequential
  Analysis software of the Copenhagen Trial Unit, <https://ctu.dk/tools>), with no
  fixed software-imposed limit on the number of looks (subject to available computational
  resources). Produces a cumulative Z-curve plot with efficacy, futility, and conventional
  significance boundaries. Methodology follows Miladinovic et al. (2013) <https://doi.org/10.1016/j.jclinepi.2012.11.007>
  and Wetterslev et al. (2009) <https://doi.org/10.1186/1471-2288-9-86>.
authors:
- family-names: Dhaouadi
  given-names: Tarak
  email: dhaouaditarak@yahoo.fr
preferred-citation:
  type: manual
  title: 'tsahr: Trial Sequential Analysis for Meta-Analyses of Hazard Ratios'
  authors:
  - family-names: Dhaouadi
    given-names: Tarak
    email: dhaouaditarak@yahoo.fr
  year: '2026'
  notes: R package
  url: https://github.com/tarak-dhaouadi/tsahr
repository: https://tarak-dhaouadi.r-universe.dev
repository-code: https://github.com/tarak-dhaouadi/tsahr
commit: fb045111e957809b2e83ac87060cdfe49cc7ebba
url: https://github.com/tarak-dhaouadi/tsahr
date-released: '2026-10-05'
contact:
- family-names: Dhaouadi
  given-names: Tarak
  email: dhaouaditarak@yahoo.fr
references:
- type: article
  title: Optimal information size in trial sequential analysis of time-to-event outcomes
    reveals potentially inconclusive results because of the risk of random error
  authors:
  - family-names: Miladinovic
    given-names: B
  - family-names: Mhaskar
    given-names: R
  - family-names: Hozo
    given-names: I
  - family-names: Kumar
    given-names: A
  - family-names: Mahony
    given-names: H
  - family-names: Djulbegovic
    given-names: B
  journal: Journal of Clinical Epidemiology
  year: '2013'
  volume: '66'
  issue: '6'
  doi: 10.1016/j.jclinepi.2012.11.007
  start: 654-659
- type: article
  title: Estimating required information size by quantifying diversity in random-effects
    model meta-analyses
  authors:
  - family-names: Wetterslev
    given-names: J
  - family-names: Thorlund
    given-names: K
  - family-names: Brok
    given-names: J
  - family-names: Gluud
    given-names: C
  journal: BMC Medical Research Methodology
  year: '2009'
  volume: '9'
  doi: 10.1186/1471-2288-9-86
  start: '86'