Package: tsahr
Type: Package
Title: Trial Sequential Analysis for Meta-Analyses of Hazard Ratios
Version: 0.2.8.18
Authors@R: c(
    person("Tarak", "Dhaouadi", email = "dhaouaditarak@yahoo.fr", role = c("aut", "cre")),
    person("Anne", "Lyngholm Soerensen", role = c("ctb", "cph"),
           comment = "author of the RTSA package, from which the boundary engine is ported"),
    person("Markus", "Harboe Olsen", role = c("ctb", "cph"),
           comment = "author of the RTSA package, from which the boundary engine is ported"),
    person("Theis", "Lange", role = c("ctb", "cph"),
           comment = "author of the RTSA package, from which the boundary engine is ported"),
    person("Christian", "Gluud", role = c("ctb", "cph"),
           comment = "author of the RTSA package, from which the boundary engine is ported"))
Description: Performs Trial Sequential Analysis (TSA) for meta-analyses
        of time-to-event outcomes reported as hazard ratios. Implements
        the Schoenfeld required-events sample-size formula generalised
        for unequal allocation, the Diversity (D-squared) heterogeneity
        adjustment of Wetterslev et al. (2009), and
        O'Brien-Fleming-type alpha- and beta-spending trial sequential
        monitoring boundaries computed at the inverse-variance
        information based on observed study-level log-HR standard
        errors (not merely event counts), via a compiled (C++)
        recursive numerical integration engine ported from the R
        package 'RTSA' (Soerensen, Olsen, Lange and Gluud; an R
        implementation of the Trial Sequential Analysis software of the
        Copenhagen Trial Unit, <https://ctu.dk/tools>), with no fixed
        software-imposed limit on the number of looks (subject to
        available computational resources). Produces a cumulative
        Z-curve plot with efficacy, futility, and conventional
        significance boundaries. Methodology follows Miladinovic et al.
        (2013) <doi:10.1016/j.jclinepi.2012.11.007> and Wetterslev et
        al. (2009) <doi:10.1186/1471-2288-9-86>.
License: GPL (>= 2)
Copyright: inst/COPYRIGHTS
Encoding: UTF-8
Depends: R (>= 4.0.0)
Imports: metafor, readxl, ggplot2 (>= 3.4.0), stats, utils, Rcpp (>=
        1.0.0)
LinkingTo: Rcpp
Suggests: testthat (>= 3.0.0), RTSA
Config/testthat/edition: 3
URL: https://github.com/tarak-dhaouadi/tsahr
BugReports: https://github.com/tarak-dhaouadi/tsahr/issues
NeedsCompilation: yes
Maintainer: Tarak Dhaouadi <dhaouaditarak@yahoo.fr>
Config/roxygen2/version: 8.1.0
Packaged: 2026-10-08 11:46:42 UTC; root
Author: Tarak Dhaouadi [aut, cre], Anne Lyngholm Soerensen [ctb, cph]
        (author of the RTSA package, from which the boundary engine is
        ported), Markus Harboe Olsen [ctb, cph] (author of the RTSA
        package, from which the boundary engine is ported), Theis Lange
        [ctb, cph] (author of the RTSA package, from which the boundary
        engine is ported), Christian Gluud [ctb, cph] (author of the
        RTSA package, from which the boundary engine is ported)
Repository: https://tarak-dhaouadi.r-universe.dev
Date/Publication: 2026-10-05 09:35:41 UTC
RemoteUrl: https://github.com/tarak-dhaouadi/tsahr
RemoteRef: HEAD
RemoteSha: fb045111e957809b2e83ac87060cdfe49cc7ebba