{ "_id": "6ac787bbde46216d5edd1b75", "Package": "tsahr", "Type": "Package", "Title": "Trial Sequential Analysis for Meta-Analyses of Hazard Ratios", "Version": "0.2.8.18", "Authors@R": "c(\nperson(\"Tarak\", \"Dhaouadi\", email = \"dhaouaditarak@yahoo.fr\", role = c(\"aut\", \"cre\")),\nperson(\"Anne\", \"Lyngholm Soerensen\", role = c(\"ctb\", \"cph\"),\ncomment = \"author of the RTSA package, from which the boundary engine is ported\"),\nperson(\"Markus\", \"Harboe Olsen\", role = c(\"ctb\", \"cph\"),\ncomment = \"author of the RTSA package, from which the boundary engine is ported\"),\nperson(\"Theis\", \"Lange\", role = c(\"ctb\", \"cph\"),\ncomment = \"author of the RTSA package, from which the boundary engine is ported\"),\nperson(\"Christian\", \"Gluud\", role = c(\"ctb\", \"cph\"),\ncomment = \"author of the RTSA package, from which the boundary engine is ported\"))", "Description": "Performs Trial Sequential Analysis (TSA) for meta-analyses\nof time-to-event outcomes reported as hazard ratios. Implements\nthe Schoenfeld required-events sample-size formula generalised\nfor unequal allocation, the Diversity (D-squared) heterogeneity\nadjustment of Wetterslev et al. (2009), and\nO'Brien-Fleming-type alpha- and beta-spending trial sequential\nmonitoring boundaries computed at the inverse-variance\ninformation based on observed study-level log-HR standard\nerrors (not merely event counts), via a compiled (C++)\nrecursive numerical integration engine ported from the R\npackage 'RTSA' (Soerensen, Olsen, Lange and Gluud; an R\nimplementation of the Trial Sequential Analysis software of the\nCopenhagen Trial Unit, ), with no fixed\nsoftware-imposed limit on the number of looks (subject to\navailable computational resources). Produces a cumulative\nZ-curve plot with efficacy, futility, and conventional\nsignificance boundaries. Methodology follows Miladinovic et al.\n(2013) and Wetterslev et\nal. (2009) .", "License": "GPL (>= 2)", "Copyright": "inst/COPYRIGHTS", "Encoding": "UTF-8", "Config/testthat/edition": "3", "URL": "https://github.com/tarak-dhaouadi/tsahr", "BugReports": "https://github.com/tarak-dhaouadi/tsahr/issues", "NeedsCompilation": "yes", "Maintainer": "Tarak Dhaouadi ", "Config/roxygen2/version": "8.1.0", "Packaged": { "Date": "2026-10-08 11:46:42 UTC", "User": "root" }, "Author": "Tarak Dhaouadi [aut, cre], Anne Lyngholm Soerensen [ctb, cph]\n(author of the RTSA package, from which the boundary engine is\nported), Markus Harboe Olsen [ctb, cph] (author of the RTSA\npackage, from which the boundary engine is ported), Theis Lange\n[ctb, cph] (author of the RTSA package, from which the boundary\nengine is ported), Christian Gluud [ctb, cph] (author of the\nRTSA package, from which the boundary engine is ported)", "Repository": "https://tarak-dhaouadi.r-universe.dev", "Date/Publication": "2026-10-05 09:35:41 UTC", "RemoteUrl": 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